Advanced Imaging for Detailed Diagnosis
The Acoustic X is a photoacoustic imaging machine that allows real-time image construction of absorber in vivo by transmitting LED pulse and detecting the ultrasonic emission resulted in photoacoustic effect. The selection of different LED wavelengths and the integration of ultrasound absorption visualize the location of the target substance.
The World’s first plug and play multispectral handheld LED-based photoacoustic and ultrasound imaging system for clinical research.
Acoustic X is capable of simultaneously obtaining information through light absorption and ultrasound. Obtained information can be displayed on the monitor of the device. By combining these two methodology, Acoustic X can display information which was thought to be difficult to display, such as capillary vessels and differences of oxygen saturation.
Support cutting-edge research
Acoustic X aims to overcome difficulties of conventional photoacoustic devices, such as the expensive costs and requirement of vast amounts of electricity supply by adopting LED array light source
Localize absorber
Detect distribution of blood (Hemoglobin)
Functional imaging (such as oxygen saturation)
Visualize artifacts such needle and marker clearly
Watch the videos and webinars to learn how Acoustic X provides unique and vast clinical and research opportunities
Featured Publications
Summary:
- First book on LED-based photoacoustic imaging
- Covers fundamentals, principles, instrumentation, reconstruction, and data/image processing methods
- Discusses the preclinical and clinical applications of LED-based photoacoustic imaging
- Includes contributions from industry and academia alike
- Highlights the opportunities and challenges of clinical translation from an industry perspective
Authors:
Yunhao Zhu, Ting Feng, Qian Cheng, Xueding Wang, Sidan Du, Naoto Sato, Jie Yuan, and Mithun Kuniyil Ajith Singh
Read moreSummary:
- First scientific review on LED-based photoacoustic imaging
- Thorough discussion about the development of technology, in a historical perspective
- Extensively reviewed the range of works from the first report on using LEDs for photoacoustic imaging to latest developments in the field
- Comparison of different illumination sources used in photoacoustic imaging (lasers, laser diodes and LEDs) in terms of cost, portability, and imaging specifications
- Summarized all the preclinical and clinical applications of LED-based photoacoustic imaging reported until early 2020
Authors:
Junggun Jo, Guan Xu, Yunhao Zhu, Mary Burton, Jeffrey Sarazin, Elena Schiopu, Girish Gandikota, and Xueding Wang
Read moreSummary:
- First clinical pilot study demonstrating the potential of LED-based photoacoustic imaging in inflammatory arthritis
- LED-photoacoustic images from 12 joints with clinically active arthritis, five joints with subclinically active arthritis, and 12 normal joints were compared with US doppler
- LED-photoacoustic imaging offered higher sensitivity than US doppler (gold standard) in detecting angiogenic microvasculature
- Clear demonstration that LED-based photoacoustic imaging is potentially an excellent portable imaging modality for inflammatory arthritis detection and treatment monitoring
Authors:
Ali Hariri, Eric Zhao, Ananthakrishna Soundaram Jeevarathinam, Jeanne Lemaster, Jianjian Zhang, and Jesse V. Jokerst
Read moreSummary:
- First preclinical study demonstrating the molecular imaging capabilities of LED-based photoacoustics
- In this work, authors measured RONS (reactive oxygen and nitrogen species) in tissue samples using a near infrared absorbing molecule (CyBA) and LED-based photoacoustic imaging
- When compared to laser-based photoacoustic imaging systems, no photobleaching was observed while using LED-based system for this highly sensitive molecular imaging application
- Besides the advantage of significant reduction in the size and cost, authors demonstrate the unprecedented potential of LED-based photoacoustics in molecular imaging
Authors:
Kalloor Joseph Francis, Yoeri E. Boink, Maura Dantuma, Mithun Kuniyil Ajith Singh, Srirang Manohar, and Wiendelt Steenbergen
Read moreSummary:
- Reported a method to realize tomographic ultrasound and photoacoustic imaging using an LED-based photoacoustic and ultrasound system
- Multiple illumination configurations suitable for human finger and animal brain imaging are explored thoroughly
- High resolution LED-based photoacoustic and ultrasound images of human finger and animal joints were obtained, demonstrating potential of the method in inflammatory arthritis diagnosis and treatment monitoring in a resource-limited preclinical and clinical setting
- Proposed method can find a wide range of clinical applications, especially in a point-of-care setting, where inexpensive and compact equipment is a requirement
Authors:
Wenfeng Xia, Mithun Kuniyil Ajith Singh, Efthymios Maneas, Naoto Sato, Yusuke Shigeta, Toshitaka Agano, Sebastian Ourselin, Simeon J. West, and Adrien E. Desjardins
Read moreSummary:
- First study demonstrating the potential of LED-based photoacoustic imaging in guiding minimally invasive procedures with peripheral vascular targets
- LED-based PA imaging offered higher contrast in visualizing clinical needle shaft and tip, when compared to ultrasound imaging, the gold standard
- Using phantom and in vivo human volunteer experiments, authors showed that combined LED-based PA and US imaging holds potential in minimally invasive surgical guidance
- Demonstrated the potential of portable LED-based system in a resource limited clinical setting for guiding procedures involving metallic clinical needles
Authors:
Qian Cheng, Menglu Qian, Xiuli Wang, Haonan Zhang, Peiru Wang, Long Wen, Jing Pan, Ya Gao, Shiying Wu, Mengjiao Zhang, Yingna Chen, Naoto Sato, and Xueding Wang
Read moreSummary:
- First clinical pilot study demonstrating the potential of LED-based photoacoustic imaging in diagnosis and treatment monitoring of port wine stain
- Thorough coverage of both the theoretical and clinical experimental aspects
- 22 patients were included in the study and the capability of LED-based PA imaging was compared with gold standard techniques like dermoscopy
- New LED-photoacoustic based index was developed which can be used as a guiding tool for port wine stain detection and PDT-based treatment monitoring
- Clearly demonstrated that LED-based photoacoustics can be a valuable tool for early diagnosis and photodynamic therapy monitoring in port wine stain disease
AcousticX Users and Collaborators
| Country | Name | Position | Department/Research Group | Institute |
|---|---|---|---|---|
| USA | Prof. Xueding Wang | Professor, Group Leader | Optical Imaging Laboratory | Michigan University |
| USA | Dr. Jesse Jokerst | Assistant Professor, Group Leader | Jokerst Bioimaging Lab | UC San Diego |
| USA | Dr. Srivalleesha Mallidi | Assistant Professor, Group Leader | Integrated Biofunctional Imaging and Therapeutics Laboratory/ Wellman Center of Photomedicine | Tufts University/Harvard Medical School |
| USA | Dr. Sri-Rajasekhar Kothapalli | Assistant Professor, Group Leader | Biophotonics and Ultrasound Imaging Laboratory | Pennsylvania State University |
| USA | Dr. Kathyayini Sivasubramanian | Post-Doctoral Fellow | Laboratory of Artificial Intelligence in Medicine and Biomedical Physics | Stanford School of Medicine |
| GBR | Prof. Adrien Desjardins | Professor, Group Leader | Interventional Devices Lab/Department of Medical Physics and Biomedical Engineering | University College London |
| GBR | Dr. Sarah Bohndiek | Professor, Junior Group Leader | VISION Lab, Department of Physics, Cavendish Laboratory | Cancer Research UK Cambridge Institute |
| GBR | Dr. Wenfeng Xia | Assistant Professor | Department of Surgical & Intervention Engineering | Kings College London |
| NLD | Prof. Wiendelt Steenbergen | Professor, Group Leader, Vice Dean - Research (TNW) | Biomedical Photonic Imaging Group | University of Twente, the Netherlands |
| DEU | Prof. Alexander Kuehne | Professor, Group Leader | Institute of Macromolecular and Organic Chemistry | Ulm University |
| ITA | Prof. Filippo Molinari | Professor, Group Leader | Biolab - Department of Electronics and Telecommunications | Politecnico di Torino |
| CHN | Prof. Qian Cheng | Professor, Group Leader | Institute of Acoustics, School of Physics Scienece and Engineering | Tongji University |
| CHN | Prof. Terence T. W. Wong | Assistant Professor | Department of Chemical and Biological Engineering | Hong Kong University of Science and Technology |
| JPN | Prof. Yoshifumi Saijo | Professor | Graduate School of Biomedical Engineering | Tohoku University |
| JPN | Prof. Ryo Suzuki | Professor | Laboratory of Drug and Gene Delivery System | Teikyo University |
| JPN | Prof. Yoichi Negishi | Professor | Department of Drug Delivery and Molecular Biopharmaceutics | Tokyo University of Pharmacy and Life Science |
| JPN | Dr. Yusuke Tajima | Senior Research Scientist | RIKEN Center for Advanced Photonics, Ultrahigh Precision Optics Technology Team | RIKEN (The Institute of Physical and Chemical Research) |
| JPN | Prof. Tetsuji Uemura | Medical Professor | University Hospital, Plastic and Reconstructive Surgery | Saga Medical School, Faculty of Medicine, Saga University |
Specifications
Maximum depth
40mm
Light source
High Density High Power LED
Wavelength can be selected from below
470, 520, 620, 660, 690,
750, 820, 850, 940, 980nm,
Combination: 690/850, 750/850, 820/940
(Can be set at 350nm to 1500nm upon request)
Frequency: Selectable from 1, 2, 3 or 4kHz
Pulse width: Selectable from 30ns to 150ns
Driver ports
4
Transducer
Selectable from 7MHz or 10MHz linear array transducer
PA processing channels
128ch parallel receiving
Scan mode
Photoacoustic 2D, Ultrasound 2D
External trigger output
For pulsed laser system
Power
AC 100 V - 240 V
Monitor
Color LCD
Software Option
3D imaging package (integrated automatic stage), oxygeneration package, High Speed Photoacoustic imaging package, Raw data accessible
Environment
No protective goggles needed
No need to define laser class
*Above figures may differ subject to options and settings.
Learn more about our products
HAL can sensor faint BES that trickle onto the skin, process it, and simultaneously assist one’s desired movement with motors located on each hip and knee joint.
Learn moreThink, Send, Read, Move—HAL is the World first neurologically controlled wearable Cyborg which puts your intentions into action. HAL improves locomotor activity in stroke, spinal cord injury and other neuromuscular disease patients.
Learn moreHAL Single Joint is a portable and lightweight unit which enables intensive and repetitive training of specific joints such as elbow, knee, and ankle.
Learn moreImproving a quality of life by ensuring your well-being, reducing fatigue in the work environment, regaining your strength and mobility, and expanding your capability.
Learn moreKeeping large facilities such as airport, shopping malls, hotels, and conference centers clean has never been easier. Find out how our cleaning and disinfection robot keeps your space tidy without the need for human operation.
Ingenious interfaces for people including those suffer from progressive neurodegenerative disease. CYIN utilizes biological information to help communicate with ease, despite all their limitations.